Michael Hochberg

Hochberg

     

  Research Director CNRS 

  External Professor Santa Fe Institute

  mhochber (at) univ-montp2 (dot) fr

  @HochTwit

 

 

CURRENT SEMINARS AND LECTURES 

Phage-bacteria community coevolution: From basic science to applications in phage therapy

Peto’s paradox in animals and within humans

Evolution as a tool for understanding cancer and its management

 

NEWS 

Fundamental Ecology is Fundamental and Back to Fundamentals

Evolutionary rationale for phages as complements of antibiotics

Phage selection for bacterial cheats leads to population decline

Dynamics of preventive versus post-diagnostic cancer control using low-impact measures

 

Screen Shot 2016-03-01 at 18.00.27

Photo credit: Alex Betts

 

RESEARCH  My objective is to produce and test a predictive theory of evolution to rapid environmental change, including the evolution of exploitation and of resistance. My laboratory uses mathematical modeling and experimental evolution with the systems surrounding Pseudomonas aeruginosa and their lytic phages. I am particularly interested in the following themes:

1. Specialization in complex evolutionary systems. We investigate how bipartite networks characteristically change during bacteriophage-bacteria coevolution. We are also currently investigating how evolutionary theory can be used to develop phage therapies and combination phage-antibiotic therapies against the nosocomial pathogen P. aeruginosa.

Poullain V., Gandon S., Brockhurst M.A., Buckling A. & Hochberg M.E. 2008. The evolution of specificity in evolving and coevolving antagonistic interactions between a bacteria and its phage. Evolution 62: 1-11  PDF

Poisot T., Thrall P.H., Bever J.D., Nemri A. & Hochberg M.E. 2011. A conceptual framework for the evolution of ecological specialisation. Ecology Letters 14: 841-851 doi: 10.1111/j.1461-0248.2011.01645.x  PDF

Poisot T., Canard E., Mouquet N. and Hochberg M.E. 2012. A comparative study of ecological specialization estimators. Methods in Ecology and Evolution 3: 537-544  PDF

Gonzalez A., Ronce O., Ferriere R. and Hochberg M.E. 2013. Evolutionary rescue: an emerging focus at the intersection between ecology and evolution. Philosophical Transactions of the Royal Society of London B 368 doi: 10.1098/rstb.2012.0404  PDF

Weitz J.S., Poisot T., Meyer J.R., Flores C.O., Valverde S., Sullivan M.B. & Hochberg M.E. 2013. Phage-bacteria infection networks. Trends in Microbiology 21: 82-91  PDF

Betts A., Kaltz O. & Hochberg M.E. 2014. Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proceedings of the National Academy of Sciences USA 111: 11109-11114  PDF

Vasse M., Torres-Barceló C. & Hochberg M.E. 2015. Phage selection for bacterial cheats leads to population decline. Proceedings of the Royal Society of London B 282, 20152207  PDF

Torres-Barceló C., Franzon B., Vasse M. & Hochberg M.E. 2016. Long-term effects of single and combined introductions of antibiotics and bacteriophages on populations of Pseudomonas aeruginosa. Evolutionary Applications  PDF

Torres-Barceló C. & Hochberg M.E. 2016. Evolutionary rationale for phages as complements of antibiotics. Trends in Microbiology  PDF

 

2. Evolution of exploitation, resistance and the dynamics of complexity in cancer. We are particularly interested in predicting tumor ecology and evolution, and the evolution of cancer resistance in the human population. We are currently developing theory of novel approaches to managing tumors at different stages of development.

Lorz A., Lorenzi T., Hochberg M.E., Clairambault J. & Perthame B. 2012. Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies. ESAIM: Mathematical Modelling and Numerical Analysis 47: 377-399  PDF

Hochberg M.E., Thomas F., Assenat E. & Hibner U. 2013. Preventive Evolutionary Medicine of Cancers. Evolutionary Applications 6: 134-143  PDF

Aktipis CA, Boddy AM, Jansen G, Hibner U, Hochberg ME, Maley C & Wilkinson GS. 2015. Cancer across the tree of life: cooperation and cheating in multicellularity. Phil. Trans. R. Soc. B 370, 20140219  PDF

Kokko H & Hochberg ME. 2015. Towards cancer-aware life-history modelling. Phil. Trans. R. Soc. B 370, 20140234  PDF

Noble R, Kaltz O & Hochberg ME. 2015. Peto’s paradox and human cancers. Phil. Trans. R. Soc. B 370, 20150104  PDF

Akhmetzhanov AR & Hochberg ME. 2015. Dynamics of preventive versus post-diagnostic cancer control using low-impact measures. eLife 10.7554/eLife.06266  PDF

 

3. The evolutionary dynamics of culture and society. We are currently developing both microscopic and macroscopic models of the innovation process.

Hochberg M.E. 2004. A theory of modern cultural shifts and meltdowns. Proceedings of the Royal Society of London B 271: S313 – S316  PDF [Correction]

Nettle D., Choisy M., Cornell H.V., Grace J.B., Guégan J-F. & Hochberg M.E. 2007. Cultural diversity, economic development and societal instability. PLoS ONE 2: E929  PDF

Marquet P., Santoro C.M., Latorre C., Standen V.G., Abades S.R., Rivadeneira M.E., and Hochberg M.E. 2012. Emergence of social complexity among coastal hunter-gatherers in the Atacama Desert of northern Chile. Proceedings of the National Academy of Sciences USA 109: 14754-14760 doi: 10.1073/pnas.1116724109  PDF

Hochberg M.E. & Whitehouse H. 2013. To Understand Present Day Cultures We Must Study the Past: a Commentary on David Sloan Wilson. Cliodynamics 4:126-128  PDF

Salali G.D., Whitehouse H. & Hochberg M.E. 2015. A Life-Cycle Model of Human Social Groups Produces a U-Shaped Distribution in Group Size. PLoS ONE  PDF

 

4. The future of science and publishing. Based on my experience as Editor in Chief of Ecology Letters I have collaborated on a number of opinion articles about credit for scientific contributions, the importance of promoting fundamental science, and the crucial role of peer review in maintaining and promoting scientific quality. Most recently, I have discussed the current general reliance on impact factors for job hires, careers, research funding, and choices on where to publish (the « impact factor syndrome »).

Tscharntke T., Hochberg M.E., Rand T.A., Resh V.H. & Krauss J. 2007. Author sequence and credit for contributions in multiauthored publications. PLoS Biology 5: e18  PDF

Hochberg M.E., Chase J.M., Gotelli N.J., Hastings A. & Naeem S. 2009. The tragedy of the reviewer commons*. Ecology Letters 12: 2-4  PDF

Hochberg M.E. 2010. Youth and the tragedy of the reviewer commons. Ideas in Ecology and Evolution 3: 8-10  PDF

Hochberg M.E. 2014. Good science depends on good peer review. Ideas in Ecology and Evolution 7: 77–82  PDF

Hochberg M.E. 2014: Reply: The Impact Factor Syndrome. Ideas in Ecology and Evolution 7: 82-83  PDF

Courchamp F., Dunne J., Le Maho Y., May R.M., Thébaud C. & Hochberg M.E. 2015. Fundamental Ecology is Fundamental. Trends in Ecology and Evolution 30: 9-15  PDF

Courchamp F., Dunne J., Le Maho Y., May R.M., Thébaud C. & Hochberg M.E. 2015. Back to the Fundamentals: a Reply to Barot et al. Trends in Ecology and Evolution 30:370-371  PDF

 

37.cover

 

Alumni now in academia

Minus van Baalen (postdoc)

Olivier Plantard (thesis)

Sam Brown (postdoc)

Corinne Vacher (thesis)

Nicolas Mouquet (postdoc)

Alex Roulin (postdoc)

Michael Brockhurst (postdoc)

Timothée Poisot (thesis)

 

 

Publications

Hochberg M.E. 1989. The potential role of pathogens in biological control. Nature 337: 262-265  PDF

Hochberg M.E., Hassell M.P. & May R.M. 1989. The dynamics of host-parasitoid-pathogen interactions. American Naturalist 135:74-94  PDF

Hochberg M.E. & Lawton J.H. 1990. Competition between kingdoms. Trends in Ecology and Evolution 5:367-371  PDF

Hochberg M.E. & Lawton J.H. 1990. Spatial heterogeneities in parasitism and population dynamics. Oikos 59:9-14  PDF

Hochberg M.E. & Holt R.D. 1990. The coexistence of competing parasites. I. The role of cross-species infection. American Naturalist 136:517-541  PDF

Hochberg M.E. 1991. Viruses as costs to gregarious feeding behaviour in the Lepidoptera. Oikos 61:291-296  PDF

Hochberg M.E. & Waage J.K. 1991. Control Engineering. Nature 352:16-17  PDF

Hochberg M.E. 1991. Intra-host interactions between a braconid endoparasitoid, Apanteles glomeratus, and a baculovirus for larvae of Pieris brassicae. Journal of Animal Ecology 60:51-63  PDF

Hochberg M.E. 1991. Extra-host interactions between a braconid endoparasitoid, Apanteles glomeratus, and a baculovirus for larvae of Pieris brassicae. Journal of Animal Ecology 60:65-77  PDF

Hochberg M.E. 1991. Population dynamic consequences of the interplay between parasitism and intraspecific competition for host-parasite systems. Oikos 61:297-306  PDF

Hochberg M.E. & Waage J.K. 1991. A model for the biological control of Oryctes rhinoceros (Coleoptera: Scarabaeidae) by means of pathogens. Journal of Applied Ecology 28: 514-531  PDF

Hochberg M.E. 1991. Non-linear transmission rates and the dynamics of infectious disease. Journal of Theoretical Biology 153:301-321  PDF

Hochberg M.E., Michalakis Y. & deMeeus T. 1992. Parasitism as a constraint on the rate of life-history evolution. Journal of Evolutionary Biology 5:491-504  PDF

Hochberg M.E., Thomas J.A. & Elmes G.W. 1992. A modelling study of the large blue butterfly, Maculinea rebeli, a parasite of red ant nests. Journal of Animal Ecology 61:397-409  PDF

Barbault R. & Hochberg M.E. 1992. Population and community level approaches to studying biodiversity in international research programs. Acta Oecologica 13: 137-146

Hochberg M.E. & Hawkins B.A. 1992. Refuges as a predictor of parasitoid diversity. Science 255:973-976  PDF

Hawkins B.A., Thomas M. & Hochberg M.E. 1993. Refuge theory and biological control. Science 262:1429-1432  PDF

Hochberg M.E. & Hawkins B.A. 1993. Predicting parasitoid diversity. American Naturalist 142:671-693  PDF

Hawkins B.A., Hochberg M.E. & Thomas M.B. 1994. Biological control and refuge theory – Reply. Science 265:812-813  PDF

Michalakis Y. & Hochberg M.E. 1994. Parasitic effects on host life-history traits: a review of recent studies. Parasite 1:291-4  PDF

Hochberg M.E. & B.A. Hawkins. 1994. The implications of population dynamics theory to parasitoid diversity and biological control. In: Parasitoid Community Ecology, eds B.A. Hawkins & W. Sheehan, pp. 451-471. Oxford University Press, Oxford  PDF

Hochberg M.E., Clarke R.T., Elmes G.W. & Thomas J.A. 1994. Population dynamic consequences of direct and indirect interactions involving a large blue butterfly and its plant and red ant hosts. Journal of Animal Ecology 63:375-391  PDF

Hochberg M.E., Menaut J.C. & Gignoux J. 1994. The influences of tree biology and fire in the spatial structure of the West African savanna. Journal of Ecology 82: 217-226  PDF

Hochberg M.E. & Holt R.D. 1995. Refuge evolution and the population dynamics of coupled host-parasitoid associations. Evolutionary Ecology 9:633-661  PDF

deMeeus T., Hochberg M.E. & Renaud F. 1995. Maintenance of two genetic entities by habitat seleciton. Evolutionary Ecology 9: 131-138  PDF

Plantard, O., Rasplus J.Y. & Hochberg M.E. 1996. Resource partitioning in the parasitoid assemblage of the oak galler Neuroterus quercusbaccarum L. (Hymenoptera: Cynipidae). Acta Oecologia 17:1-15  PDF

Hochberg M.E. 1996. An integrative paradigm for the dynamics of monophagous parasitoid-host interactions. Oikos 77:556-560  PDF

Hochberg M.E., Elmes G.W., Thomas J.A. & Clarke R.T. 1996. Mechanisms of local persistence in coupled host-parasitoid associations: the case model of Maculinea rebeli and Ichneumon eumerus. Philosophical Transactions of the Royal Society of London B 351:1713-1724  PDF

Elmes G.W., Clarke R.T., Thomas J.A. & Hochberg M.E. 1996. Empirical tests of specific predictions made from a spatial model of the population dynamics of Maculinea rebeli, a parasitic butterfly of red ant colonies. Acta Oecolgica 17:61-80  PDF

Hochberg M.E. 1996. When three is a crowd. Nature 381: 276-277  PDF

Hochberg M.E. 1996. Consequences for host population levels of increasing natural enemy species richness in classical biological control. American Naturalist 147: 307-318  PDF

Clarke R.T., Elmes G.W., Thomas J.A. & Hochberg M.E. 1997. The effects of spatial patterns in habitat quality on community dynamics within a site. Proceedings of the Royal Society of London B 264:347-354  PDF

Lemel J.Y., Belichon S., Clobert J. & Hochberg M.E. 1997. The evolution of dispersal in a two-patch system: Some consequences of differences between migrants and residents. Evolutionary Ecology 11:613-629  PDF

Hawkins B.A., Cornell H.V. & Hochberg M.E. 1997. Predators, parasitoids, and pathogens as mortality agents in phytophagous insect populations. Ecology 78:2145-2152  PDF

Holt R.D. & Hochberg M.E. 1997. When is biological control evolutionarily stable (or is it)? Ecology 78: 1673-1683  PDF

Thomas J.A., Elmes G.W., Clarke R.T., Munguira M.L. & Hochberg M.E. 1997. Field evidence and model predictions of butterfly-mediated apparent competition between gentian plants and red ants. Acta Oecologica 18:671-84  PDF

Kerdelhué C., Hochberg M.E. & Rasplus J.Y. 1997. Active pollination of Ficus sur by two sympatric fig wasp species in West Africa. Biotropica 29:69-75  PDF

Hochberg M.E. 1997. Hide of fight? The competitive evolution of concealment and encapsulation in parasitoid-host assocations. Oikos 80:342-352  PDF

Cornell H.V., Hawkins B.A. & Hochberg M.E. 1998. Towards an empirically-based theory of herbivore demography. Ecological Entomology 23:340-349  PDF

Thomas J.A., Simcox D.J., Wardlaw J., Elmes G.W., Hochberg M.E. & Clarke R.T. 1998. Effects of latitude, altitude and climate on the habitat and conservation of the endangered butterfly Maculinea arion and its Myrmica ant hosts. Journal of Insect Conservation 2:39-46  PDF

Clarke R.T., Thomas J.A., Elmes G.W., Wardlaw J.C., Munguira M.L. & Hochberg M.E. 1998. Population modelling of the spatial interactions between Maculinea rebeli their intitial foodplant Gentiana cruciata and Myrmica ants within a site. Journal of Insect Conservation 2:29-37  PDF

Elmes G.W., Thomas J.A., Wardlaw J., Hochberg M.E., Clarke R.T. & Simcox D. 1998. The ecology of Myrmica ants in relation to the conservation of Maculinea butterflies. Journal of Insect Conservation 2:67-78  PDF

Hochberg M.E., Elmes G.W., Thomas J.A. & Clarke R.T. 1998. Effects of habitat reduction on the persistence of Ichneumon eumerus (Hymenoptera: Ichneumonidae), the specialist parasitoid of Maculinea rebeli (Lepidoptera: Lycaenidae). Journal of Insect Conservation 2:59-66  PDF

Plantard O. & Hochberg M.E. 1998. Factors affecting parasitism in the oak-galler Neuroterus quercusbaccarum (Hymeoptera: Cynipidae). Oikos 81:289-298  PDF

Holt R.D. & Hochberg M.E. 1998. The coexistence of competing parasites. II. Hyperparasitism and food chain dynamics. Journal of Theoretical Biology 193:485-495  PDF

Hochberg M.E. & van Baalen M. 1998. Antagonistic coevolution over productivity gradients. American Naturalist 152:620-634  PDF

Hochberg M.E. 1998. Establishing genetic correlations involving parasite virulence. Evolution 52: 1865-1868  PDF

Thomas J.A., Clarke R.T., Elmes G.W. & Hochberg M.E. 1998. Population dynamics in the genus Maculinea (Lepidoptera: Lycaenidae). In: Insect Populations in Theory and Practice. Pages 261-290. Dempster J.P. & McLean I.F.G. (Eds.). Kluwer Academic

Hochberg M.E. 1998. The population dynamic role of monophagous parasitoids: some ecological and evolutionary inroads to a synthesis. Population and Community Ecology for Insect Management and Conservation. Pages 169-174. Baumgartener J., Brandmayr P. & Manly B.F.J. (Eds.). Balkema.

Robert M., Sorci G., Møller A.P., Hochberg M.E., Pomiankowski A. & Pagel M. 1999. Retaliatory cuckoos and the evolution of host resistance to brood parasites. Animal Behavior 58:817-824  PDF

Hochberg M.E. & Holt R.D. 1999. The uniformity and density of pest exploitation as guides to success in biological control. Pages 71-88 in B.A. Hawkins and H.V. Cornell, eds. Theoretical Approaches to Biological Control. Cambridge University Press, Cambridge, UK  PDF

Holt R.D., Hochberg M.E. and Barfield M. 1999. Population dynamics and the evolutionary stability of biological control. Pages 219-230 in B.A. Hawkins and H.V. Cornell, eds. Theoretical Approaches to Biological Control. Cambridge University Press, Cambridge, UK  PDF

Hochberg M.E. & Ives A.R. 1999. Can natural enemies enforce geographical range limits? Ecography 22: 268-276  PDF

Hochberg M.E. & Ives A.R. 2000. Introduction. Pages 3-14. in M. E. Hochberg and A. R. Ives, editors. Parasitoid Population Biology. Princeton University Press, Princeton.

Hochberg M.E. 2000. What, Conserve Parasitoids?  Pages 266-277. in M. E. Hochberg and A. R. Ives, editors. Parasitoid Population Biology. Princeton University Press, Princeton.

Ives A.R. & Hochberg M.E. 2000. Conclusions: debating parasitoid population biology over the next twenty years. Pages 278-304 in M. E. Hochberg and A. R. Ives, editors. Parasitoid Population Biology. Princeton University Press, Princeton.

Hochberg M.E. & van Baalen M. 2000. A geographical perspective of virulence. Pages 81-96 in: Evolutionary biology of host-parasite relationships: Theory meets reality. R. Poulin, S. Morand & A. Skorping, eds. Elsevier Science  PDF

Hochberg M.E., Gomulkiewicz R., Holt R.D. & Thompson J.N. 2000. Weak sinks could cradle mutualistic symbioses —strong sources should harbor pathogenic symbioses. Journal of Evolutionary Biology 13 : 213-222  PDF

Gomulkiewicz R., Thompson J.N., Holt R.D., Nuismer S.L. & Hochberg M.E. 2000. Hot spots, cold spots, and the geographic mosaic theory of coevolution. American Naturalist 156 : 156-174  PDF

Weis A.E. & Hochberg M.E. 2000. The diverse effects of intra-specific competition on selection for resistance: a model and its predictions. American Naturalist 156: 276-292  PDF

Weis A.E., Simms E.L. & Hochberg M.E. 2000. Will plant vigor and tolerance be genetically correlated? Effects of intrinsic growth rate and self-limitation on regrowth. Evolutionary Ecology 14: 331-352  PDF

Guégan J-F., Thomas F., Hochberg M.E., deMeeus T. & Renaud F. 2001. Disease diversity and human fertility. Evolution 55: 1308-1314  PDF

van Baalen M. & Hochberg M.E. 2001. Dispersal in antagonistic interactions. Pages 299-310 in Dispersal. Causes, consequences and mechanisms of dispersal at the individual, population and community level.  J. Clobert. E. Danchin. A.A. Dhont. & J. Nichols (Eds.). Oxford University Press.

Hochberg M.E. & Moller A.P. 2001. Insularity and adaptation in coupled victim-enemy associations. Journal of Evolutionary Biology 14: 539-551  PDF

Holt R.D. and Hochberg M.E. 2001. Indirect interactions, community modules, and biological control: a theoretical perspective. Pages 13-37 in E. Waijnberg, J.K. Scott and P.C. Quimby, eds. Evaluation of Indirect Ecological Effects of Biological Control. CAB International  PDF

Bertault G., Rousset F., Fernandez D., Berthomieu A., Hochberg M.E., Callot G. & Raymond M. 2001. Population genetics and dynamics of the black truffle in a man-made truffle field. Heredity 86: 451-458  PDF

Hochberg M.E. & Weis A.E. 2001. Ecology – Bagging the lag. Nature 409: 992-993  PDF

Restif O., Hochberg M.E. & Koella J.C. 2001. Virulence at the edge of reproduction: new insights into host-parasite coevolution. Journal of Evolutionary Biology 14: 967-979  PDF

Shaw, M.R. & Hochberg, M.E. 2001. The neglect of parasitic Hymenoptera in insect conservation strategies: the British fauna as a prime example. Journal of Insect Conservation 5: 253-263  PDF

Dedeine F., Vavre F., Fleury F., Hochberg M.E. & Boulétreau M. 2001. Removing symbiotic Wolbachia bacteria specifically inhibits oogenesis in a parasitic wasp. Proceedings of the National Academy of Sciences USA 98: 6247-6252  PDF

Holt R.D. and Hochberg M.E. 2002. Virulence on the edge:  a source-sink perspective. Pages 104-120 in U. Dieckmann, J.A.J. Metz, M.W. Sabelis and K. Sigmund, eds. Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management. Cambridge University Press, Cambridge, UK   PDF

Brown S.P., Hochberg M.E. & Grenfell B. 2002. Does multiple infection select for raised virulence? Trends in Microbiology 10: 401-405  PDF

Hochberg, M. E. and Holt R.D. 2002. Biogeographical perspectives of arms races. Pages 197-209 in U. Dieckmann, J.A.J. Metz, M.W. Sabelis and K. Sigmund, eds. Adaptive Dynamics of Infectious Diseases : In Pursuit of Virulence Management. Cambridge University Press, Cambridge, UK  PDF

Lynch L.D., Ives A.R., Waage J.K. Hochberg M.E. & Thomas M.B. 2002. The risks of biocontrol: Transient impacts and minimum nontarget densities. Ecological Applications 12: 1872-1882  PDF

Hochberg M.E., Sinervo B. & Brown S.P. 2003. Socially mediated speciation. Evolution 57: 154-158  PDF

Hochberg M.E., Berthault G., Poitrineau K. & Janssen A. 2003. Olfactory orientation of the truffle beetle, Leiodes cinnamomea. Entomologia Experimentalis et Applicata 109: 147-153  PDF

Poitrineau K., Brown S.P. & Hochberg M.E. 2003. Defence against multiple enemies. Journal of Evolutionary Biology 16: 1319-1327  PDF

Vacher C., Bourguet D., Rousset F., Chevillon C. and M.E. Hochberg. 2003. Modelling the spatial configuration of refuges for a sustainable control of pests: a case study of Bt cotton. Journal of Evolutionary Biology 16: 378-387  PDF

Vacher C., Bourguet D., Rousset F., Chevillon C. and M.E. Hochberg. 2004. High dose refuge strategies and genetically modified crops – Reply to Tabashnik et al. Journal of Evolutionary Biology 17: 913-918  PDF

Vacher C., Weis A.E., Hermann D., Kossler T., Young C. & Hochberg M.E. 2004. Impact of ecological factors on the initial invasion of Bt transgenes into wild populations. Theoretical and Applied Genetics 109: 806-14  PDF

Hochberg M.E. 2004. A theory of modern cultural shifts and meltdowns. Proceedings of the Royal Society of London B 271: S313 – S316  PDF [Correction]

Guernier V., Hochberg M.E. & Guégan J-F. 2004. Ecology drives the global distribution of human diseases. PLoS Biology 2: e186  PDF

Poitrineau K., Brown S.P. & Hochberg M.E. 2004. The joint evolution of defence and inducibility against natural enemies. Journal of Theoretical Biology 231: 389-396  PDF

André J-P. & Hochberg M.E. 2005. Virulence evolution in emerging infectious diseases. Evolution 59: 1406-1412  PDF

Mouquet N., Belrose V., Thomas J.A., Elmes G.W., Clarke R.T. & Hochberg M.E. 2005. Conserving community modules: a case study of the endangered lycaenid butterfly Maculinea alcon. Ecology 86: 3160-3173  PDF

Mouquet N., Thomas J.A., Elmes G.W., Clarke R.T. & Hochberg M.E. 2005. Population dynamics and conservation of a specialized predator: A case study of Maculinea arion. Ecological Monographs 75: 525-542  PDF

Vacher C., Brown S.P.& Hochberg M.E. 2005. Avoid, attack or do both? Behavioral and physiological adaptations in natural enemies faced with novel hosts. BMC Evolutionary Biology 5: 60  PDF

Clarke R.T., Mouquet N., Thomas J.A., Hochberg M.E., Elmes G.W., Tesar D., Singer A. & Hale J. 2005. Modelling the local population dynamics of Maculinea and their spatial interactions with their larval foodplant and Myrmica ant species. In: Studies on the Ecology and Conservation of Butterflies in Europe. Vol. 2: Species Ecology along a European Gradient: Maculinea Butterflies as a Model, J. Settele, E. Kühn & J.A. Thomas (Eds) pp 115-119. Pensoft, Sofia.

Buckling A., Wei Y., Massey R.C., Brockhurst M.A. & Hochberg M.E. 2006. Antagonistic coevolution with parasites increases the cost of host deleterious mutations. Proceedings of the Royal Society of London B 273: 45-9  PDF

Sinervo B., Chaine A., Clobert J., Calsbeek R., Hazard L., Lancaster L., McAdam A.G., Alonzo S., Corrigan G., Hochberg M.E. 2006. Self-recognition, color signals, and cycles of greenbeard mutualism and altruism. Proceedings of the National Academy of Sciences 103: 7372-7377  PDF

Vacher C., Bourguet D., Desquilbet M., Lemarié S., Ambec S. & Hochberg M.E. 2006. Fees or refuges: which is better for the sustainable management of insect resistance to transgenic Bt corn? Biology Letters 2: 198 – 202  PDF

Brockhurst M.A., Hochberg M.E., Bell T. & Buckling A. 2006. Character displacement promotes cooperation in bacterial biofilms. Current Biology 16:2030-2034  PDF

Brockhurst M.A., Buckling A., Poullain V. & Hochberg M.E. 2007. The impact of migration from parasite-free patches on antagonistic host-parasite coevolution. Evolution 61: 1238-1243  PDF

Thrall P.H., Hochberg M.E., Burdon J.J. & Bever J.D. 2007. Coevolution of symbiotic mutualists and parasites in a community context. Trends in Ecology and Evolution 22: 120-126  PDF

Tscharntke T., Hochberg M.E., Rand T.A., Resh V.H. & Krauss J. 2007. Author sequence and credit for contributions in multiauthored publications. PLoS Biology 5: e18  PDF

Hovestadt T., Mitesser O., Elmes G.W., Thomas J.A. & Hochberg M.E. 2007. An evolutionary stable strategy model for the evolution of dimorphic development in the butterfly Maculinea rebeli, a social parasite of Myrmica ant colonies. American Naturalist 169: 466-480  PDF

Nettle D., Choisy M., Cornell H.V., Grace J.B., Guégan J-F. & Hochberg M.E. 2007. Cultural diversity, economic development and societal instability. PLoS ONE 2: E929  PDF

Poullain V., Gandon S., Brockhurst M.A., Buckling A. & Hochberg M.E. 2008. The evolution of specificity in evolving and coevolving antagonistic interactions between a bacteria and its phage. Evolution 62: 1-11  PDF

Venail P., MacLean R.C., Bouvier T., Brockhurst M.A., Hochberg M.E. & Mouquet N. 2008. Diversity and productivity peak at intermediate dispersal rate in evolving metacommunities. Nature 452:210-214  PDF

Urban M.C., Leibold M.A., Pantel J.H., Loeuille N., Vellend M., Amarasekare P., Klausmeier C.A., Norberg J., de Mazancourt C., Gomulkiewicz R., Hochberg M.E., Strauss S.Y., De Meester L. & Wade M.J. 2008. The evolutionary ecology of metacommunities. Trends in Ecology and Evolution 23:311-317  PDF

Hochberg M.E., Rankin D.J. & Taborsky M. 2008. The coevolution of cooperation and dispersal in social groups and its implications for the emergence of multicellularity. BMC Evolutionary Biology 8:238  PDF Table of Examples

Hochberg M.E., Chase J.M., Gotelli N.J., Hastings A. & Naeem S. 2009. The tragedy of the reviewer commons*. Ecology Letters 12: 2-4  PDF

Vogwill T., Fenton A., Buckling A., Hochberg M.E. & Brockhurst M.A. 2009. Source populations act as coevolutionary pacemakers in experimental selection mosaics containing hotspots and coldspots. American Naturalist 173: E171-176  PDF

Escobar-Paramo P., Faivre N., Buckling A., Gougat-Barbera C. & Hochberg M.E. 2009. Persistence of costly novel genes in the absence of positive selection. Journal of Evolutionary Biology 22: 536-543  PDF

Hochberg M.E. 2010. Book Review for The American Journal of Human Biology: The Mermaid’s Tale: Four Billion Years of Cooperation in the Making of Living Things. American Journal of Human Biology 22: 227-228  PDF

Hochberg M.E. 2010. Youth and the tragedy of the reviewer commons. Ideas in Ecology and Evolution 3: 8-10  PDF

Sagarin R.D., Alcorta C.S, Atran S., Blumstein D.T., Dietl G.P., Hochberg M.E., Johnson D.D.P., Levin S., Madin E.M.P., Madin J.S., Prescott E.M., Sosis R., Taylor T., Tooby J. & Vermeij G.J.. 2010. Decentralize, adapt and cooperate. Nature 465: 292-293  PDF

Poisot T., Lepennetier G., Martinez E., Ramsayer J. & Hochberg M.E. 2011. Resource availability affects the structure of a natural bacteria–bacteriophage community. Biology Letters 7: 201-204 doi:10.1098/rsbl.2010.0774  PDF Supp Info

Vacher C., Kossler T.M., Hochberg M.E. & Weis A.E. 2011. Impact of interspecific hybridization between crops and weedy relatives on the evolution of flowering time in weedy phenotypes. PLoS ONE 6: e14649  PDF

Gravel D., Guichard F. & Hochberg M.E. 2011. Coexistence in a variable world. Ecology Letters 14: 828-839 doi: 10.1111/j.1461-0248.2011.01643.x  PDF

Poisot T., Thrall P.H., Bever J.D., Nemri A. & Hochberg M.E. 2011. A conceptual framework for the evolution of ecological specialisation. Ecology Letters 14: 841-851 doi: 10.1111/j.1461-0248.2011.01645.x  PDF

Poisot T., Thrall P.H. and Hochberg M.E. 2011. Trophic network structure emerges through antagonistic coevolution in temporally varying environments. Proceedings of the Royal Society of London B 279: 299-308 doi:10.1098/rspb.2011.0826  PDF

Ramsayer J., Fellous S., Cohen J.E. and Hochberg M.E.. 2011. Taylor’s Law holds in experimental bacterial populations but competition does not influence the slope. Biology Letters 23: 316-319 doi:10.1098/rsbl.2011.0895  PDF

Lorz A., Lorenzi T., Hochberg M.E., Clairambault J. & Perthame B. 2012. Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies. ESAIM: Mathematical Modelling and Numerical Analysis 47: 377-399  PDF

Poisot T., Canard E., Mouquet N. and Hochberg M.E. 2012. A comparative study of ecological specialization estimators. Methods in Ecology and Evolution 3: 537-544  PDF

Escobar-Páramo P., Gougat-Barbera C. & Hochberg M.E. 2012. Evolutionary dynamics of separate and combined exposure of Pseudomonas fluorescens SBW25 to antibiotics and bacteriophage. Evolutionary Applications 5: 583-592 doi: 10.1111/j.1752-4571.2012.00248.x  PDF

Kaltz O., Escobar-Paramo P., Hochberg M.E. and Cohen J.E. 2012. Bacterial microcosms obey Taylor’s law: effects of abiotic and biotic stress and genetics on mean an variance of population density. Ecological Processes 1:5  PDF

Marquet P., Santoro C.M., Latorre C., Standen V.G., Abades S.R., Rivadeneira M.E., and Hochberg M.E. 2012. Emergence of social complexity among coastal hunter-gatherers in the Atacama Desert of northern Chile. Proceedings of the National Academy of Sciences USA 109: 14754-14760 doi: 10.1073/pnas.1116724109  PDF

Blumstein D.T., Atran S., Field S., Hochberg M.E., Johnson D.D.P., Sagarin R., Sosis R. & Thayer B. 2012. The peacock’s tale: Lessons from evolution for effective signalling in international politics. Cliodynamics: The Journal of Theoretical and Mathematical History 3:191-214  PDF

Whitehouse H., Kahn K., Hochberg M.E. and Bryson J.J. 2012. The role for simulations in theory construction for the social sciences: case studies concerning Divergent Modes of Religiosity. Religion, Brain and Behavior 2:182-201  PDF

Whitehouse H., Kahn K., Hochberg M.E. and Bryson J.J. 2012. RESPONSE: From the imaginary to the real: the back and forth between reality and simulation. Religion, Brain and Behavior 2: 219-224  PDF

Hochberg M.E. 2012. There is no (single) Holy Grail  EDGE

Roche B., Hochberg M.E., Caulin A.F., Maley C.C., Gatenby R.A., Missé D. & Thomas F. 2012. Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox. BMC Cancer 12:387  PDF

Poisot T., Bell T., Martinez E., Gougat-Barbera C. & Hochberg M.E. 2013. Terminal investment induced by a bacteriophage in a rhizosphere bacterium. F1000Research 1:21  PDF

Gonzalez A., Ronce O., Ferriere R. and Hochberg M.E. 2013. Evolutionary rescue: an emerging focus at the intersection between ecology and evolution. Philosophical Transactions of the Royal Society of London B 368: 20120404  PDF

Gandon S., Hochberg M.E., Holt R.D. and Day T. 2013. What limits the evolutionary emergence of pathogens?  Philosophical Transactions of the Royal Society of London B 368: 20120086  PDF

Weitz J.S., Poisot T., Meyer J.R., Flores C.O., Valverde S., Sullivan M.B. & Hochberg M.E.  2013.  Phage-bacteria infection networks. Trends in Microbiology 21: 82-91  PDF

Thomas F., Fisher D., Fort P., Marie J-P., Daoust S., Roche B., Grunau C., Cosseau C., Mitta G., Baghdiguian S., Rousset F., Lassus P., Assenat E., Grégoire D., Missé D., Lorz A., Billy F., Vainchenker W., Delhommeau F., Koscielny S., Itzykson R., Tang R., Fava F., Ballesta A., Lepoutre T., Krasinska L.,  Dulic V., Raynaud P., Blache P., Quittau-Prevostel C., Vignal E., Trauchessec H., Perthame B., Clairambault J., Volpert V., Solary E., Hibner U. & Hochberg M.E. 2013. Applying ecological and evolutionary theory to cancer: a long and winding road. Evolutionary Applications 6: 1-10  PDF

Hochberg M.E., Thomas F., Assenat E. & Hibner U.  2013.  Preventive Evolutionary Medicine of Cancers. Evolutionary Applications 6: 134-143  PDF

Ramsayer J., Kaltz O. & Hochberg M.E. 2013. Evolutionary rescue in populations of Pseudomonas fluorescens across an antibiotic gradient. Evolutionary Applications 6:608-616  PDF

Poisot T.,  Lounnas, M, & Hochberg M.E. 2013. The structure of natural microbial enemy-victim networks. Ecological Processes 2: 13 doi:10.1186/2192-1709-2-13  PDF

Betts A., Vasse M., Kaltz O. & Hochberg M.E. 2013. Back to the future: Evolving bacteriophages to increase their effectiveness against the pathogen Pseudomonas aeruginosa PAO1. Evolutionary Applications 6: 1054-1063  PDF

Hochberg M.E. & Whitehouse H. 2013. To Understand Present Day Cultures We Must Study the Past: a Commentary on David Sloan Wilson. Cliodynamics 4:126-128  PDF

Luque G., Hochberg M.E., Holyoak M., Hossaert M., Gaill F. & Courchamp F. 2013.  Ecological effects of environmental change. Ecology Letters 16: 1–3  PDF

Betts A., Kaltz O. & Hochberg M.E. 2014. Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proceedings of the National Academy of Sciences USA 111: 11109-11114  PDF

Poisot T., Bever J.D., Thrall P.H. & M.E. Hochberg. 2014. Dispersal and spatial heterogeneity allow coexistence between enemies and protective mutualists. Ecology & Evolution 4:3841-3850  PDF

Torres-Barceló C., Arias-Sánchez F.I., Vasse M., Ramsayer J., Kaltz O. & Hochberg M.E. 2014. A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages. PLOS ONE 9:e106628  PDF

Hochberg M.E. 2014. Good science depends on good peer review. Ideas in Ecology and Evolution 7: 77–82  PDF

Hochberg M.E. 2014: Reply: The Impact Factor Syndrome. Ideas in Ecology and Evolution 7: 82-83  PDF

Hochberg M.E. & Brown J.H. 2014. Tragedy of The Tragedy of the Commons. Ideas in Ecology and Evolution  PDF

Noble R., Kaltz O. & Hochberg M.E. 2015. Statistical interpretations and new findings on Variation in Cancer Risk Among Tissues. arXiv q-bio arXiv:1502.01061  PDF

Courchamp F., Dunne J., Le Maho Y., May R.M., Thébaud C. & Hochberg M.E. 2015. Fundamental Ecology is Fundamental. Trends in Ecology and Evolution 30:9-15  DOI 10.1016/j.tree.2014.11.005  PDF

Courchamp F., Dunne J., Le Maho Y., May R.M., Thébaud C. & Hochberg M.E. 2015. Back to the Fundamentals: a Reply to Barot et al. Trends in Ecology and Evolution 30:370-371  PDF

Hochberg M.E. and Jansen G. 2015. Bacteria: Assessing resistance to new antibiotics. Nature 519: 158  PDF (Unpublished technical version)

Poisot T., Kéfi S., Morand S., Stanko M., Marquet P.A. & Hochberg M.E. 2015. A Continuum of Specialists and Generalists in Empirical Communities. PLOS ONE 10(5): e0114674  PDF

Nunney L, Maley CC, Breen M, Hochberg ME & Schiffman JD. 2015. Peto’s paradox and the promise of comparative oncology. Phil. Trans. R. Soc. B 370: 20140177  PDF

Aktipis CA, Boddy AM, Jansen G, Hibner U, Hochberg ME, Maley C & Wilkinson GS. 2015. Cancer across the tree of life: cooperation and cheating in multicellularity. Phil. Trans. R. Soc. B 370, 20140219  PDF

Kokko H & Hochberg ME. 2015. Towards cancer-aware life-history modelling. Phil. Trans. R. Soc. B 370, 20140234  PDF

Noble R, Kaltz O & Hochberg ME. 2015. Peto’s paradox and human cancers. Phil. Trans. R. Soc. B 370, 20150104  PDF

Akhmetzhanov AR & Hochberg ME. 2015. Dynamics of preventive versus post-diagnostic cancer control using low-impact measures. eLife 10.7554/eLife.06266  PDF

Salali G.D., Whitehouse H. & Hochberg M.E. 2015. A Life-Cycle Model of Human Social Groups Produces a U-Shaped Distribution in Group Size. PLoS ONE  PDF

Vasse M., Torres-Barceló C. & Hochberg M.E. 2015. Phage selection for bacterial cheats leads to population decline. Proceedings of the Royal Society of London B 282, 20152207; DOI: 10.1098/rspb.2015.2207  PDF

Torres-Barceló C. & Hochberg M.E. 2016. Evolutionary rationale for phages as complements of antibiotics. Trends in Microbiology  PDF

Torres-Barceló C., Franzon B., Vasse M. & Hochberg M.E. Accepted. Long-term effects of single and combined introductions of antibiotics and bacteriophages on populations of Pseudomonas aeruginosa. Evolutionary Applications  PDF

 

Edited Volumes

Hochberg M.E., Clobert J. & Barbault R. 1996. Aspects of the Genesis and Maintenance of Biological Diversity. Oxford University Press

Combes C., Hudson P. & Hochberg M.E. 1996. Host-parasite co-evolution. Biodiversity and Conservation

Hochberg M.E. & Ives A.R. 2000. Parasitoid Population Biology. Princeton University Press

Hochberg M.E. & Gotelli N.J. 2005. An invasions special issue. Trends in Ecology and Evolution

Gonzalez A., Ronce O., Ferrière R. & Hochberg M.E. 2013. Evolutionary Rescue. Philosophical Transactions of the Royal Socieity of London

Thomas F., Hibner U., Maley CC., Aktipis C.A. & Hochberg M.E. 2013. Evolution and Cancer. Evolutionary Applications

Holyoak M. & Hochberg M.E. 2013. Ecological effects of environmental change. Ecology Letters

Schiffman J., Maley C.C., Nunney L., Hochberg M. & Breen M. 2015. Cancer across life: Peto’s paradox and the promise of comparative oncology. Philosophical Transactions of the Royal Society of London B

Mike Hochberg